Dr. Divyesh H. Shastri, M.Pharm, Ph.D., Postdoc (USA)
Associate Professor
Department of Pharmaceutics & Pharmaceutical Technology
Year Started @ KBIPER: 2006
Contact info
Location: KBIPER College Campus/KSVV
Email: divyeshshastri@gmail.com, divyesh.shastri@kbiper.ac.in
Credentials
Postdoc., The State University of New York, NY, USA
Ph.D., Hemchandracharya North Gujarat University, Patan, Gujarat
M. Pharm., Gujarat University, Ahmedabad, Gujarat
B. Pharm., Gujarat University, Gandhinagar, Gujarat
D. Pharm., North Gujarat Unversity, Modasa, Gujarat
Profile
Dr. Divyesh Shastri is working at KBIPER since September 2006 as an Assistant Professor in Department of Pharmaceutics & Pharmaceutical Technology. He has 16 years of academic and research experience in the area of drug delivery system.
Dr. Shastri has completed his post-doctoral research on novel formulation development for protein therapeutics, in vitro and in vivo evaluation of the formulation, and quantitative analysis of the experimental results using PK/PD Modeling and Simulation at the State University of New York, USA.
At KBIPER, along with teaching, Dr. Shastri is actively involved in research activities and he has published and presented his work in various national and international journals and conferences, respectively. He has guided more than fifteen M. Pharm. Students and twenty undergraduate students for research project work. He has received research grant from KSV for research project on Nanoparticulate insitu gelling system. He has also delivered guests lectures in IPA and PCI Sponsored refresher course for registered pharmacist, AICTE sponsored staff development program, GUJCOST sponsored state level competitions. Dr. Shastri is actively involved in National Service Scheme (NSS) as a Program Officer, and coordinating work related to alumni association, industrial visits, and university examinations. Under his guidance and supervision, first time in the history, pharmacy students have received regional, state as well as Indira Gandhi National Awards in NSS and brought the name of KBIPER at national level. He also serves as a general secretary of Indian Pharmacy Graduate's Association (IPGA), Gujarat state branch and has been involved in the related activities.
Research area of Interest
Delivery of protein therapeutics i.e., mAb, ScFv, Fab and Fab2 etc., PKPD modeling and simulation using MATLAB, Gastroplus, Baysian & Torsten, formulation development of Hydrogel, nanoparticulate in situ gel forming system for Ophthalmic, Nasal & Pulmonary route and parenteral extended-release, Oral floating, buccal film, microsponge and self-micro-emulsifying Drug Delivery System.
Research Interest / Area
  • Delivery of protein therapeutics i.e., mAb, ScFv, Fab and Fab2 etc., its quantitative analysis using PKPD modeling and simulation (Berkeley Madonna, ADAPT-V (population PK), Baysian, Torsten, MATLAB, Symbiology, S-ADAPT, simCYP.
  • Ocular: In-situ gel and Nanoparticulate Drug Delivery, Ocular film as a Drug Delivery system, Nasal, Oral and Pulmonary Drug Delivery,
  • Floating matrix tablet as Drug Delivery, Liqui-solid System, Chewing-gum based Drug Delivery, Buccal film and, Hotmelt granulation Technology
  • Synthesis and Modification of the biodegradable polymers like Thiolated Chitosan, PEGylated Chitosan, Trimethyl Chitosan etc., for controlled and sustained drug delivery.
  • Self-Micro-Emulsifying Drug Delivery system.
  • Topical DDS: Transdermal DDS, Micro-sponge-based DDS
  • Parenteral Extended-Release DDS.
Awards and Recognition
  1. Received fellowship from Research foundation of SUNY, NY, USA for the Post-doctoral research at USA for the research work on drug delivery of protein therapeutics and its PKPD studies.
  2. Received research grant from Kadi Sarva Vishwavidyalaya, Gandhinagar for research project entitled "Nanoparticulate Insitu gel forming system against Bacterial Keratoconjunctivitis" for the year 2012-2015.
  3. Received "International Travel ship Award" under ITS scheme of Department of Science and Technology, New Delhi, for research paper presentation at Annual Meeting and Exposition of American Association of Pharmaceutical Scientists (AAPS) held at McCormick Place, Chicago, USA during 14th to 18th October 2012.
  4. Travel Grant from All India Council of Technical Education, New Delhi, for Ph. D. research paper presentation at Annual Meeting and Exposition of American Association of Pharmaceutical Scientists (AAPS) held at Georgia, Atlanta, USA during 16th to 20th November 2008.
  5. Junior Research Fellowship from All India Council of Technical Education, New Delhi 2002-2004.
Honors and Awards (Local, National and International):
  • Received fellowship from Research Foundation of SUNY, USA for the Post-doctoral research at USA for the research work on novel formulation development for protein therapeutics, in vitro and in vivo evaluation of the formulation, and quantitative analysis of the experimental results using PK/PD Modeling and Simulation at the State University of New York, USA.
  • Received Research Grant from Kadi Sarva Vishwavidyalaya, Gandhinagar of about 7.0 lakhs for Research Project on "Formulation Development and Evaluation of Nanoparticulate in-situ gel forming system for the treatment of ocular Keratoconjunctivitis" for the year 2012-2015.
  • Received "International Travel ship Award" under ITS scheme of Department of Science and Technology, New Delhi, for Research paper presentation at Annual Meeting and Exposition of American Association of Pharmaceutical Scientists (AAPS) held at McCormick Place, Chicago, USA during 14th to 18th October 2012.
  • First prize in paper presentation at Charusat University Jan 2012 entitled: "Drug Nanocrystals: Future Technology for the Development of a New Innovative Formulation".
  • Received "AICTE TRAVEL GRANT" under faculty scheme of AICTE, New Delhi, for Paper presentation at Annual Meeting and exposition of American Association of Pharmaceutical Scientists (AAPS)-2008, held during 16th to 20th November at Atlanta, Georgia, USA.
  • Graduate scholarship during the period of September 2002 and October 2004, supported by DST, India.
  • Secured 99.04 percentile with 43rd rank (AIR) All over India in Graduate Aptitude Test in Engineering (GATE - 2002) conducted by Indian Institute of Science, Bangalore.
  • 9th Rank in final year Bachelors University exam (2002)
Memberships
  • Gen Secretary of Indian Pharmacy Graduates Association, Gujarat State Branch
  • Life Member of APTI
  • Indian Society of Pharmacognosists
  • Advances in biological Science Society
  • Gujarat Pharmacy Teachers Association
  • Association of Community Pharmacists of India
Selected publications/presentations
  1. DH Shastri, P Gautam. Formulation and Evaluation of New Self-Micro-Emulsifying Mouth Dissolving Film of Azilsartan. International Journal of Pharmacy & Pharmaceutical Research. 20(2); 112-134: 2021.
  2. DH Shastri, DJ Modi. Fluidized Hot-melt Granulation Technique: An Approach to Improve Micromeritics Properties and Dissolution Rate of Efavirenz. International Journal of Pharmaceutical Sciences and Drug Research. 12(5);554-560:2020. DOI: 10.25004/IJPSDR.2020.120518.
  3. DH Shastri, DJ Modi. To Explore Potential of Fluidized Hot-melt granulation technique to improve micromeritics properties and dissolution rate of Modafinil. J. of Emerging Technologies and Innovative Research (JETIR). Article ID: JETIR1905T57. 6(5);1799-1807:2019.
  4. DH Shastri, PM Oza. Sustained Release Thiolated Chitosan based nanoparticulate in situ gel for Ocular Delivery Prulifloxacin. Current Nanomedicine. 7(3):2017. DOI: 10.2174/2468187307666170104154707.
  5. DH Shastri. Thiolated Chitosan: A boon to ocular drug delivery. Int. J. Bioavailability and Bioequivalence (MOJBB), Med Crave Science. Article ID: 00029. 3(2);1-3:2017.
  6. A Patel, HD Dodiya, DH Shastri. Design, Characterization, and Optimization of Controlled Drug Delivery System Containing Antibiotic Drug/s. J. Drug Delivery. Hindawi Publications. Article ID 9024173;15:2016. DOI: http://dx.doi.org/10.1155/2016/9024173.
  7. A Bhanupriy, DH Shastri, HD Dodiya, PK Shelat. Formulation Development and Evaluation of a Gastro-retentive in situ oral gel of Cefuroxime Axetil. J. Young Pharm. 8(4):324-329;2016. DOI: 10.5530/jyp.2016.4.6.
  8. NP Kala, DH Shastri, PK Shelat. (2015). Design and Characterization of Buccoadhesive Liqui-solid System of an Antihypertensive Drug. J. Drug Delivery, Hindawi Publications. Article ID:574247. 9:2015. DOI. http://dx.doi.org/10.1155/2015/574247.
  9. NP Kala, MT Shaikh, DH Shastri, PK Shelat. A Review on Liqui-solid system. J. Drug Deliv. Thera. 4 (3), 25-31; 2014. CITATIONS: 7.
  10. DH Shastri, PB Patel, PK Shelat, AK Shukla and GB Shah. Design and Characterization of ofloxacin mucoadhesive in situ hydrogel. Afr. J. Pharm. Pharmacol. 6(23): 1644-1652:2012. DOI: 10.5897/AJPP11.485. ISSN: 1996-0816, IF:0.84.
  11. Shastri DH, Menon SK, Joshi K, Modi N. Evaluation and solubility improvement of Carvedilol - PSC[n]arene inclusion complexes with Acute Oral toxicity studies. Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2012;73(1-4), 295-303.
  12. Shastri DH, Patel PB, Shelat PK, Shukla AK, Shah GB. Design and characterization of ofloxacin mucoadhesive in situ hydrogel. African Journal of Pharmacy and Pharmacology. 2012;6(23):1644-52.
  13. Patel KK, Mehta NJ, Dhandhalia MC, Bhanupriy AK, Shastri DH, Shelat PK, Shah GB. Development and Evaluation of Herbal Anti-Acne Formulation. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2012;3(3):334-339.
  14. Patel PB, Shastri DH, Shelat PK, Shukla AK. Development of pH triggered in-situ ophthalmic gel formulation of ofloxacin. American Journal of Pharm Tech Research. 2011;1(4):430-45.
  15. Shastri DH, Prajapati S, Patel L. Thermoreversible mucoadhesive ophthalmic in situ hydrogel: Design and optimization using a combination of polymers. Acta pharmaceutica. 2010;60(3):349-60.
  16. Shastri DH, Prajapati ST, Patel LD. Design and development of thermoreversible ophthalmic in situ hydrogel of moxifloxacin HCl. Current drug delivery. 2010;7(3):238-43.
  17. Shastri DH, Patel LD. A novel alternative to ocular drug delivery system: Hydrogel. Int J Pharm Res. 2010;2:1-13.
  18. Shastri DH, Prajapati ST, Parikh RK, Patel LD. Studies on Poloxamer Based Mucoadhesive Ophthalmic In Situ Hydrogel of Moxifloxacin HCl. Int J Pharm Res. 2010;1(3):77-86.
  19. Shastri DH, Patel LD, Parikh RK. Studies on in situ hydrogel: a smart way for safe and sustained ocular drug delivery. Journal of Young Pharmacists. 2010;2(2):116-20.
  20. Shastri DH, Patel LD. Optimization of polyox based thermoreversible mucoadhesive ophthalmic in-situ hydrogel using 32 full factorial design. Inventi Impact: Pharm Tech. 2010;1(1):40-44.
  21. Shastri DH, Parikh RK, Patel LD. Studies on In situ Hydrogel: A Smart Way for Safe and Sustained Ocular Drug Delivery. Journal of Young Pharmacy. Elsevier Publication. 2006;2(2):116-120.